Ag-Presenting CpG-Activated pDCs Prime Th17 Cells That Induce Tumor Regression
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چکیده
منابع مشابه
Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.
Plasmacytoid dendritic cells (pDC) rapidly and massively produce type I IFN and other inflammatory cytokines in response to foreign nucleic acids, thereby indirectly influencing T-cell responses. Moreover, antigen (Ag)-presenting pDCs directly regulate T-cell differentiation. Depending on the immune environment, pDCs exhibit either tolerogenic or immunogenic properties. Here, we show that CpG-a...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2014
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-14-1149